Pharmacology Information Systems
Pharmacological Information Systems represents a major force in the treatment of various forms of illness, and many companies are interested in supporting research and development in this area.
Relevant topics include, but are not limited to:
1.Methods to evaluate old and new chemical entities (including complex mixtures of crude extracts from natural products) for possible therapeutic usefulness using “in vitro” and “in vivo” assays and model systems.
2.Methods for extraction, fractionalization, and isolation of active compounds from natural products. Water-soluble compounds are of particular interest due to the difficulty of the procedures.
3.Computer algorithms that model receptors to evaluate theoretical permutations of known molecules to find the molecule with the maximum probability of having the highest affinity for a specific receptor as well as those that have the potential for the most desirable “on” and “off” rates.
4.Computer models of the blood brain barrier and evaluate potential and actual drug molecules for their ability to cross or penetrate this barrier.
5.Strategies for evaluating pharmacological agents (e.g., animal behavioral testing, computer simulation) within specific domains of cognitive function.
6.Behavioral “models” similar in animals and humans; behavioral pharmacological effects that may serve as “surrogate” markers in humans.
7.Development of models for evaluating drug effects within functional brain circuits relevant to mental disorders.
8.Development of novel drug delivery systems.
9.Tools for Drug Development including neuroimaging (e.g., radiolabeled compounds) and development of animal models.
All of these contingent methodologies require new and innovative approaches to data collection and report distribution that contain a closer connection to working models connected to verifiable measurements. And the key to verification is well structured database systems.
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Author: Tom Gruich
Technorati Tags: databases, robotics, science, sensors, Telemetry
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